Genome-Wide Identification of Fitness Factors in Seawater for Edwardsiella piscicida

Author:

Wei Lifan1,Wu Yanyan1,Yang Guanhua1,Xu Rongjing2,Liu Xiaohong134,Liu Qin134,Zhang Yuanxing134,Ma Yue134,Wang Qiyao134

Affiliation:

1. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China

2. Yantai Tianyuan Aquatic Co. Ltd., Yantai, Shandong, China

3. Shanghai Engineering Research Center of Maricultured Animal Vaccines, Shanghai, China

4. Shanghai Collaborative Innovation Center for Biomanufacturing, Shanghai, China

Abstract

Edwardsiella piscicida is one of the most important marine pathogens and causes serious edwardsiellosis in farmed fish during the summer-autumn seasonal changes, resulting in enormous losses to aquaculture industries worldwide. Survival and transmission of the pathogen in seawater are critical steps that increase the risk of outbreaks. To investigate the mechanism of survival in seawater for this marine pathogen, we used transposon insertion sequencing analysis to explore the fitness determinants in summer and autumn seawater. Approximately 127 genes linked to metabolism and virulence, as well as other processes, were revealed in E. piscicida to contribute to better adaptations to the seasonal alternations of seawater environments; these genes provide important insights into the infection outbreak mechanisms of E. piscicida and potential improved treatments or vaccines against marine pathogens.

Funder

Ministry of Agriculture of China

Science and Technology Commission of Shangdong

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

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