In Vitro Activity of Sulopenem, an Oral Penem, against Urinary Isolates of Escherichia coli-Reference-Cited by-同舟云学术

In Vitro Activity of Sulopenem, an Oral Penem, against Urinary Isolates of Escherichia coli

Published:2019-01 Issue:1 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Karlowsky James A.¹,Adam Heather J.¹,Baxter Melanie R.¹,Denisuik Andrew J.¹,Lagacé-Wiens Philippe R. S.¹,Walkty Andrew J.¹,Puttagunta Sailaja²,Dunne Michael W.²,Zhanel George G.¹

Affiliation:

1. Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada

2. Iterum Therapeutics, Old Saybrook, Connecticut, USA

Abstract

The in vitro activity of sulopenem was assessed against a collection from 2014 to 2016 of 539 urinary isolates of Escherichia coli from Canadian patients by using CLSI-defined broth microdilution methodology. A concentration of sulopenem 0.03 µg/ml inhibited both 50% (MIC 50 ) and 90% (MIC 90 ) of isolates tested; sulopenem MICs ranged from 0.015 to 0.25 µg/ml.

Funder

University of Manitoba

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01832-18

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