Impact of acquired broad-spectrum β-lactamases on susceptibility to oral penems/carbapenems (tebipenem, sulopenem, and faropenem) alone or in combination with avibactam and taniborbactam β-lactamase inhibitors in Escherichia coli

Author:

Le Terrier Christophe12ORCID,Nordmann Patrice134,Bouvier Maxime13,Poirel Laurent13

Affiliation:

1. Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg , Fribourg, Switzerland

2. Division of Intensive Care Unit, University Hospitals of Geneva , Geneva, Switzerland

3. Swiss National Reference Center for Emerging Antibiotic Resistance , Fribourg, Switzerland

4. University of Lausanne and University Hospital Center , Lausanne, Switzerland

Abstract

ABSTRACT The impact of β-lactamases on susceptibility to oral penems/carbapenems (tebipenem, sulopenem, and faropenem) and other carbapenem molecules was evaluated in Escherichia coli , alone and in combination with avibactam or taniborbactam β-lactamase inhibitors. Tebipenem and sulopenem exhibited a similar spectrum of activity compared to the intravenous carbapenems and displayed lower MIC values than ceftibuten-avibactam against E. coli producing extended-spectrum β-lactamases or AmpC enzymes. Combined with taniborbactam, tebipenem and sulopenem exhibited low MIC values against almost all tested recombinant E. coli , including metallo-β-lactamase producers.

Funder

University of Fribourg

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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