The Reaction Mechanism of Metallo-β-Lactamases Is Tuned by the Conformation of an Active-Site Mobile Loop-Reference-Cited by-同舟云学术

The Reaction Mechanism of Metallo-β-Lactamases Is Tuned by the Conformation of an Active-Site Mobile Loop

Published:2019-01 Issue:1 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Palacios Antonela R.¹,Mojica María F.²³,Giannini Estefanía¹,Taracila Magdalena A.³⁴,Bethel Christopher R.³,Alzari Pedro M.⁵^ORCID,Otero Lisandro H.⁶⁷,Klinke Sebastián⁶⁷^ORCID,Llarrull Leticia I.¹⁸,Bonomo Robert A.²³⁴⁹¹⁰,Vila Alejandro J.¹⁷⁸¹¹

Affiliation:

1. Instituto de Biología Molecular y Celular de Rosario (IBR, CONICET-UNR), Ocampo y Esmeralda, Rosario, Argentina

2. Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

3. Research Service, Louis Stokes Veterans Affairs Medical Center, Cleveland, Ohio, USA

4. Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

5. Institut Pasteur, Unite de Microbiologie Structurale, CNRS UMR 3528/Université Paris Diderot, Paris, France

6. Fundación Instituto Leloir, IIBBA-CONICET, Buenos Aires, Argentina

7. Plataforma Argentina de Biología Estructural y Metabolómica PLABEM, Buenos Aires, Argentina

8. Área Biofísica, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina

9. Departments of Medicine, Pharmacology, Molecular Biology and Microbiology, Biochemistry, Proteomics, and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

10. Medical Service and GRECC, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA

11. Case VA CARES (CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology), Cleveland, Ohio, USA

Abstract

Carbapenems are “last resort” β-lactam antibiotics used to treat serious and life-threatening health care-associated infections caused by multidrug-resistant Gram-negative bacteria. Unfortunately, the worldwide spread of genes coding for carbapenemases among these bacteria is threatening these life-saving drugs.

Funder

HHS | National Institutes of Health

MINCyT | Agencia Nacional de Promoción Científica y Tecnológica

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01754-18

Reference83 articles.

1. Bacterial Resistance to β-Lactam Antibiotics: Compelling Opportunism, Compelling Opportunity

2. Bonomo RA Tolmasky M. 2007. Enzyme-mediated resistance to antibiotics: mechanisms dissemination and prospects for inhibition 1st ed vol 83. ASM Press Washington DC.