Bisthiazolidines: A Substrate-Mimicking Scaffold as an Inhibitor of the NDM-1 Carbapenemase

Author:

González Mariano M.1,Kosmopoulou Magda2,Mojica Maria F.3,Castillo Valerie4,Hinchliffe Philip2,Pettinati Ilaria5,Brem Jürgen5,Schofield Christopher J.5,Mahler Graciela4,Bonomo Robert A.3,Llarrull Leticia I.1,Spencer James2,Vila Alejandro J.1

Affiliation:

1. Instituto de Biologı́a Molecular y Celular de Rosario (IBR-CONICET), Facultad de Ciencias Bioquı́micas y Farmacéuticas, Universidad Nacional de Rosario (UNR), Ocampo y Esmeralda, 2000 Rosario, Argentina

2. School of Cellular and Molecular Medicine, Medical Sciences Building, University of Bristol, University Walk, Bristol BS8 1TD, United Kingdom

3. Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, and Departments of Pharmacology, Biochemistry, Microbiology, and Molecular Biology, Case Western Reserve University, Cleveland, Ohio 44106, United States

4. Laboratorio de Quı́mica Farmacéutica, Facultad de Quı́mica, Universidad de la República (UdelaR), Montevideo 11800, Uruguay

5. Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, United Kingdom

Funder

National Institute of Allergy and Infectious Diseases

Consejo Nacional de Investigaciones Científicas y Técnicas

Medical Research Council

Agencia Nacional de Promoción Científica y Tecnológica

U.S. Department of Veterans Affairs

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

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