Synergistic Activities of Moxifloxacin Combined with Piperacillin-Tazobactam or Cefepime against Klebsiella pneumoniae , Enterobacter cloacae , and Acinetobacter baumannii Clinical Isolates-Reference-Cited by-同舟云学术

Synergistic Activities of Moxifloxacin Combined with Piperacillin-Tazobactam or Cefepime against Klebsiella pneumoniae , Enterobacter cloacae , and Acinetobacter baumannii Clinical Isolates

Published:2004-03 Issue:3 Volume:48 Page:1055-1057
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Jung Rose¹,Husain Maroof¹,Choi Michael K.¹,Fish Douglas N.¹

Affiliation:

1. Antimicrobial Research Laboratory, Department of Clinical Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado 80262

Abstract

ABSTRACT The bactericidal activity of moxifloxacin alone and in combination with cefepime or piperacillin-tazobactam against clinical isolates of Klebsiella pneumoniae , Enterobacter cloacae , and Acinetobacter baumannii was evaluated by using time-kill methods and antimicrobial concentrations of one-half and one times the MIC. Synergy was observed in 58 to 88% of the strains and resulted in bactericidal activity against 60 to 100% of the strains. Combinations including moxifloxacin demonstrated enhanced bactericidal activity compared with that of either agent tested alone.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.48.3.1055-1057.2004

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