Affiliation:
1. Department of Internal Medicine, Ohio State University College of Medicine, Columbus 43210, USA. fass.1@osu.edu
Abstract
MICs of Bay 12-8039 and comparative antimicrobials were determined for 820 recent clinical isolates. Ciprofloxacin was approximately 2-fold more active than Bay 12-8039 and ofloxacin against Enterobacteriaceae and approximately 8-fold more active against Pseudomonas aeruginosa. Bay 12-8039 was approximately 2- to 16-fold more active than ciproiloxacin and ofloxacin against nonfermenters (except P. aeruginosa), staphylococci, streptococci, enterococci, and anaerobes. As determined by regression analysis, there was a high degree of correlation among quinolone MICs.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference11 articles.
1. Cross-resistance and cross-susceptibility between fluoroquinolone agents;Barry A. L.;Eur. J. Clin. Microbiol. Infect. Dis.,1991
2. In vitro activity of ciprofloxacin (Bay o 9867);Fass R. J.;Antimicrob. Agents Chemother.,1983
3. In vitro activity of Bay y 3118, a new quinolone;Fass R. J.;Antimicrob. Agents Chemother.,1993
4. Use of frequency distribution curves, scattergrams and regression analyses to compare in vitro activities and describe cross-susceptibility and cross-resistance among four quinolones;Fass R. J.;J. Chemother.,1994
5. In vitro activities of quinolones, ~-lactams, tobramycin, and trimethoprim-sulfamethoxazole against nonfermentative gram-negative bacilli;Fass R. J.;Antimicrob. Agents Chemother.,1996
Cited by
82 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献