Production and Biological Activity of Secalonic Acid D-Reference-Cited by-同舟云学术

Production and Biological Activity of Secalonic Acid D

Published:1980-02 Issue:2 Volume:39 Page:285-287
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Ciegler Alex¹,Hayes A. Wallace²,Vesonder Ronald F.³

Affiliation:

1. Southern Regional Research Center, Science and Education Administration, U.S. Department of Agriculture, New Orleans, Louisiana 70179

2. University of Mississippi Medical Center, Jackson, Mississippi 39216

3. Northern Regional Research Center, Science and Education Administration, U.S. Department of Agriculture, Peoria, Illinois 61604

Abstract

Twenty isolates of Penicillium oxalicum produced secalonic acid as their major secondary metabolite. Fermentation conditions were determined for toxin production in grain and liquid media. The 50% lethal dose value for mice ranged from 26.5 to 51.7 mg/kg dependent on animal strain and sex, males being more susceptible than females. Secalonic acid was nontoxic and nonteratogenic to the chicken embryo and exhibited poor antibiotic properties. Its potential role in mycotoxicoses is discussed.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/aem.39.2.285-287.1980

Reference12 articles.

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3. Production and biological activity ofpatulin and citrinin from Penicillium expansum;Ciegler A.;Appl. Environ. Microbiol.,1977

4. Fungal metabolites. Part 1. Stereochemical features and m spectrometry of secalonic acids;Howard C. C.;J. Chem. Soc. Perkin Trans.,1973

5. Aflatoxin and Aspergillus flavus occurrence in 1975 corn at harvest from a limited region of Iowa;Lillehoj E. B.;Cereal Chem.,1977

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