Produciton and biological activity of patulin and citrinin from Penicillium expansum

Author:

Ciegler A,Vesonder R F,Jackson L K

Abstract

Penicillium expansum isolated from meat and apples produced both patulin and citrinin. Toxin identity was confirmed by spectroscopic and physical methods. The mean lethal dose in chicken embryos was determined for toxins administered both singly and in various ratios. Data from simultaneous administration of mycotoxin combinations plotted as isobolograms showed and additive effect. Both toxins were teratogenic in chicken embryos.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Reference7 articles.

1. Teratogenicity of patulin and patulin adducts formed with cysteine;Ciegler A.;Appl. Environ. Microbiol.,1976

2. Untersuchungen uber das Toxinbildungsvermogen von Rohwursten isolierter Schimmelpilze der Gattung Penicillium;Ciegler A.;Fleischwirtschaft,1972

3. A revision of two computer programs for probit analysis;Daum R. J.;Bull. Entomol. Soc. Am.,1970

4. Occurrence of patulin andc patulin-producing strains of Penicillium expansum in natural rots of apple in Canada;Harwig J.;Can. Inst. Food Sci. Technol. J.,1973

5. Measurement of the potencies of drug mixtures;Hewlett P. S.;Biometrics,1969

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