Transcriptional Modulator NusA Interacts with Translesion DNA Polymerases in Escherichia coli-Reference-Cited by-同舟云学术

Transcriptional Modulator NusA Interacts with Translesion DNA Polymerases in Escherichia coli

Published:2009-01-15 Issue:2 Volume:191 Page:665-672
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Cohen Susan E.¹,Godoy Veronica G.²,Walker Graham C.¹

Affiliation:

1. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

2. Department of Biology, Northeastern University, Boston, Massachusetts 02115

Abstract

ABSTRACT NusA, a modulator of RNA polymerase, interacts with the DNA polymerase DinB. An increased level of expression of dinB or umuDC suppresses the temperature sensitivity of the nusA11 strain, requiring the catalytic activities of these proteins. We propose that NusA recruits translesion DNA synthesis (TLS) polymerases to RNA polymerases stalled at gaps, coupling TLS to transcription.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.00941-08

Reference52 articles.

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