Human Herpesvirus 8 Gene Encodes a Functional Thymidylate Synthase-Reference-Cited by-同舟云学术

Human Herpesvirus 8 Gene Encodes a Functional Thymidylate Synthase

Published:2002-10-15 Issue:20 Volume:76 Page:10530-10532
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Gáspár Gábor¹²,De Clercq Erik¹,Neyts Johan¹

Affiliation:

1. Rega Institute for Medical Research, Leuven, Belgium

2. Department of Medical Microbiology, University of Szeged, Szeged, Hungary

Abstract

ABSTRACT We demonstrate that human herpesvirus 8, obtained from the lymphoma cell line BC-3 as well as from Kaposi's sarcoma lesions, carries a gene that encodes a functional thymidylate synthase (TS). The particular characteristics of this enzyme are studied and compared to the characteristics of TSs encoded by other organisms.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.76.20.10530-10532.2002

Reference23 articles.

1. Balzarini, J., E. De Clercq, M. P. Mertes, D. Shugar, and P. F. Torrence. 1982. 5-Substituted 2′-deoxyuridines: correlation between inhibition of tumor cell growth and inhibition of thymidine kinase and thymidylate synthetase. Biochem. Pharmacol. 31 : 3673-3682.

2. Barr, P. J., N. J. Oppenheimer, and D. V. Santi. 1983. Thymidylate synthetase-catalyzed conversions of E-5-(2-bromovinyl)-2′-deoxyuridylate. J. Biol. Chem. 258 : 13627-13631.

3. Human Herpesvirus 8-Encoded Thymidine Kinase and Phosphotransferase Homologues Confer Sensitivity to Ganciclovir

4. Carreras, C. W., S. C. Climie, and D. V. Santi. 1992. Thymidylate synthase with a C-terminal deletion catalyzes partial reactions but is unable to catalyze thymidylate formation. Biochemistry 31 : 6038-6044.

5. Cinquina, C. C., E. Grogan, R. Sun, S. F. Lin, G. P. Beardsley, and G. Miller. 2000. Dihydrofolate reductase from Kaposi's sarcoma-associated herpesvirus. Virology 268 : 201-217.

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