Rewiring of the Host Cell Metabolome and Lipidome during Lytic Gammaherpesvirus Infection Is Essential for Infectious-Virus Production-Reference-Cited by-同舟云学术

Rewiring of the Host Cell Metabolome and Lipidome during Lytic Gammaherpesvirus Infection Is Essential for Infectious-Virus Production

Published:2023-06-29 Issue:6 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Clark Sarah A.¹^ORCID,Vazquez Angie²,Furiya Kelsey²,Splattstoesser Madeleine K.²,Bashmail Abdullah K.²,Schwartz Haleigh¹^ORCID,Russell Makaiya²,Bhark Shun-Je²^ORCID,Moreno Osvaldo K.³,McGovern Morgan²^ORCID,Owsley Eric R.²,Nelson Timothy A.²^ORCID,Sanchez Erica L.³⁴^ORCID,Delgado Tracie²¹^ORCID

Affiliation:

1. Northwest University, Department of Biology, Kirkland, Washington, USA

2. Seattle Pacific University, Department of Biology, Seattle, Washington, USA

3. San Francisco State University, Department of Biology, San Francisco, California, USA

4. University of Texas at Dallas, Department of Biological Sciences, Richardson, Texas, USA

Abstract

Viruses are intracellular parasites which lack their own metabolism, so they must hijack host cell metabolic machinery in order to increase the production of energy, proteins, fats, and genetic material necessary to replicate. Using murine herpesvirus 68 (MHV-68) as a model system to understand how similar human gammaherpesviruses cause cancer, we profiled the metabolic changes that occur during lytic MHV-68 infection and replication.

Funder

M.J. Murdock Charitable Trust

John Templeton Foundation

Northwest University Ray and Shirley Clark Faculty Research Grant

Seattle Pacific University Faculty Research and Scholarship Grant

Genentech Foundation

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00506-23

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