Affiliation:
1. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine
2. Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan
Abstract
ABSTRACT
Many single-celled eukaryotes produce prostaglandin-like molecules, but these have not been absolutely verified by mass spectrometry. We have isolated, and identified by liquid chromatography-tandem mass spectrometry, authentic prostaglandin E
2
from
Cryptococcus neoformans
. Cyclooxygenase inhibitors did not inhibit prostaglandin synthesis, and the cryptococcal genome lacks a cyclooxygenase homolog. Thus, novel enzymes must exist.
Publisher
American Society for Microbiology
Subject
Molecular Biology,General Medicine,Microbiology
Cited by
42 articles.
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