30S Ribosomal Subunit Assembly Is a Target for Inhibition by Aminoglycosides in Escherichia coli-Reference-Cited by-同舟云学术

30S Ribosomal Subunit Assembly Is a Target for Inhibition by Aminoglycosides in Escherichia coli

Published:2002-05 Issue:5 Volume:46 Page:1546-1549
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Mehta Roopal¹,Champney W. Scott¹

Affiliation:

1. Department of Biochemistry and Molecular Biology, J. H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614

Abstract

ABSTRACT The aminoglycosides paromomycin and neomycin were examined in Escherichia coli cells for an inhibitory effect on 30S ribosomal subunit assembly. Both compounds inhibited the growth rate, viable cell number, and protein synthesis rate with similar 50% inhibitory concentrations. Each drug also showed a concentration-dependent inhibition of 30S subunit formation. The inhibitory effect on 30S particle formation was approximately equivalent to the inhibitory effect on translation for these antibiotics.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.46.5.1546-1549.2002

Reference20 articles.

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3. 50S ribosomal subunit synthesis and translation are equivalent targets for erythromycin inhibition in Staphylococcus aureus

4. Champney, W. S., and R. Burdine. 1998. Azithromycin and clarithromycin inhibition of 50S ribosomal subunit formation in Staphylococcus aureus cells. Curr. Microbiol.36:119-123.

5. Champney, W. S., and C. L. Tober. 2001. Structure-activity relationships for six ketolide antibiotics. Curr. Microbiol.42:203-210.

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