50S ribosomal subunit synthesis and translation are equivalent targets for erythromycin inhibition in Staphylococcus aureus-Reference-Cited by-同舟云学术

50S ribosomal subunit synthesis and translation are equivalent targets for erythromycin inhibition in Staphylococcus aureus

Published:1996-05 Issue:5 Volume:40 Page:1301-1303
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Champney W S¹,Burdine R¹

Affiliation:

1. Department of Biochemistry, J.H.Quillen College of Medicine, East Tennessee, State University, Johnson City 37614, USA.

Abstract

Macrolide antibiotics like erythromycin can prevent the formation of the 50S ribosomal subunit in growing bacterial cells, in addition to their inhibitory effect on translation. The significance of this novel finding has been further investigated. The 50% inhibitory doses of erythromycin for the inhibition of translation and 50S subunit assembly in Staphylococcus aureus cells were measured and were found to be identical. Together they account quantitatively for the observed effects of erythromycin on cell growth rates. There is also a direct relationship between the loss of rRNA from the 50S subunit and its accumulation as oligoribonucleotides in cells. The importance of this second site for erythromycin inhibition of bacterial cell growth is discussed.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.40.5.1301

Reference11 articles.

1. Champney W. S. Unpublished data.

2. Macrolide antibiotics inhibit 50S ribosomal subunit assembly in Bacillus subtilis and Staphylococcus aureus;Champney W. S.;Antimicrobial Agents Chemother.,1995

3. Erythromycin inhibits the assembly of the large ribosomal subunit in growing Escherichia coli cells;Chittum H. S.;Curr. Microbiol.,1995

4. Corcoran J. W. 1984. Mode of action and resistance mechanisms of macrolides p. 231-259. In S. Omura (ed.) Macrolide antibiotics. Academic Press Inc. Orlando Fla.

5. On the nature of antibiotic binding sites in ribosomes;Cundliffe E.;Biochimie,1987

Cited by 43 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Biochemical Inhibitors for Algae;Research Methods of Environmental Physiology in Aquatic Sciences;2020-12-22

2. Antibiotics targeting bacterial ribosomal subunit biogenesis;Journal of Antimicrobial Chemotherapy;2020-01-13

3. A Numbers Game: Ribosome Densities, Bacterial Growth, and Antibiotic-Mediated Stasis and Death;mBio;2017-03-08

4. Ribosome Assembly as Antimicrobial Target;Antibiotics;2016-05-27

5. Chemical modulators of ribosome biogenesis as biological probes;Nature Chemical Biology;2015-11-17