Structural Basis of Covalent Inhibitory Mechanism of TMPRSS2-Related Serine Proteases by Camostat-Reference-Cited by-同舟云学术

Structural Basis of Covalent Inhibitory Mechanism of TMPRSS2-Related Serine Proteases by Camostat

Published:2021-09-09 Issue:19 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Sun Gaohui¹,Sui Yaqun¹,Zhou Yang¹,Ya Junlin¹,Yuan Cai²,Jiang Longguang¹³^ORCID,Huang Mingdong¹^ORCID

Affiliation:

1. College of Chemistry, Fuzhou University, Fuzhou, Fujian, People’s Republic of China

2. College of Biological Science and Engineering, Fuzhou University, Fuzhou, Fujian, People’s Republic of China

3. Fujian Key Laboratory of Marine Enzyme Engineering, Fuzhou University, Fuzhou, Fujian, People’s Republic of China

Abstract

Serine proteases are a large family of enzymes critical for multiple physiological processes and proven diagnostic and therapeutic targets in several clinical indications. The serine protease transmembrane protease serine 2 (TMPRSS2) was recently found to mediate SARS-CoV-2 entry into the host.

Funder

National Key R&D Program of China

National Natural Science Foundation of China

Natural Science Foundation of Fujian Province

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00861-21

Reference35 articles.

1. A pneumonia outbreak associated with a new coronavirus of probable bat origin