Herpes Simplex Virus 1 Can Bypass Impaired Epidermal Barriers upon Ex Vivo Infection of Skin from Atopic Dermatitis Patients

Author:

Möckel Maureen1,De La Cruz Nydia C.1,Rübsam Matthias23,Wirtz Lisa13,Tantcheva-Poor Iliana4,Malter Wolfram5,Zinser Max6,Bieber Thomas7,Knebel-Mörsdorf Dagmar18ORCID

Affiliation:

1. Center for Biochemistry, University Hospital Cologne, University of Cologne, Cologne, Germany

2. Department Cell Biology of the Skin, University Hospital Cologne, University of Cologne, Cologne, Germany

3. Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, University Hospital Cologne, University of Cologne, Cologne, Germany

4. Department of Dermatology, University Hospital Cologne, University of Cologne, Cologne, Germany

5. Department of Gynecology and Obstetrics, University Hospital Cologne, University of Cologne, Cologne, Germany

6. Department of Plastic, Reconstructive and Aesthetic Surgery, University Hospital Cologne, University of Cologne, Cologne, Germany

7. Department of Dermatology and Allergy, Christine Kühne-Center for Allergy Research and Education, University Hospital Bonn, Bonn, Germany

8. Department of Pediatrics, University Hospital Cologne, University of Cologne, Cologne, Germany

Abstract

Herpes simplex virus 1 (HSV-1) can target skin to establish primary infection in the epithelium. While the human skin provides effective barriers against viral invasion under healthy conditions, a prominent example of successful invasion is the disseminated HSV-1 infection in the skin of atopic dermatitis (AD) patients.

Funder

Koln Fortune Program/Faculty of Medicine

Maria-Pesch foundation

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference52 articles.

1. Singh M, Goodyear HM, Breuer J. 2020. Herpes simplex virus infections. In Hoeger P, Kinsler V, Yan A, Harper J, Oranje A, Bodemer C, Larralde M, Luk D, Mendiratta V, Purvis D (ed), Harper’s textbook of pediatric dermatology, 4th ed. Wiley, New York, NY.

2. Eczema Herpeticum

3. Atopic dermatitis

4. Which Way Do We Go? Complex Interactions in Atopic Dermatitis Pathogenesis

5. Molecular pathogenesis and clinical implications of eczema herpeticum

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