Ex Vivo Infection of Human Skin Models with Herpes Simplex Virus 1: Accessibility of the Receptor Nectin-1 during Formation or Impairment of Epidermal Barriers Is Restricted by Tight Junctions

Author:

De La Cruz Nydia C.1,Möckel Maureen1,Niehues Hanna2,Rübsam Matthias34,Malter Wolfram5,Zinser Max6,Krummenacher Claude7ORCID,Knebel-Mörsdorf Dagmar18ORCID

Affiliation:

1. Center for Biochemistry, University Hospital Cologne, University of Cologne, Cologne, Germany

2. Department of Dermatology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands

3. Department Cell Biology of the Skin, University Hospital Cologne, University of Cologne, Cologne, Germany

4. Cologne Excellence Cluster on Cellular Stress Response in Aging-associated Diseases, University Hospital Cologne, University of Cologne, Cologne, Germany

5. Department of Gynecology and Obstetrics, University Hospital Cologne, University of Cologne, Cologne, Germany

6. Department of Plastic, Reconstructive and Aesthetic Surgery, University Hospital Cologne, University of Cologne, Cologne, Germany

7. Department of Biological and Biomedical Sciences, Rowan University, Glassboro, New Jersey, USA

8. Department of Pediatrics, University Hospital Cologne, University of Cologne, Cologne, Germany

Abstract

Herpes simplex virus 1 (HSV-1) is a widely distributed human pathogen which productively infects epithelia. The open question is which barriers of the highly protected epithelia must the virus overcome to reach its receptor nectin-1.

Funder

Deutsche Forschungsgemeinschaft

Koeln Fortune Program Medical faculty

Pesch foundation

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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