Inhibition of membrane potential-dependent amino acid transport by daptomycin-Reference-Cited by-同舟云学术

Inhibition of membrane potential-dependent amino acid transport by daptomycin

Published:1991-12 Issue:12 Volume:35 Page:2639-2642
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Allen N E¹,Alborn W E¹,Hobbs J N¹

Affiliation:

1. Infectious Disease Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285-0428.

Abstract

Daptomycin inhibits the formation of UDP-N-acetylmuramyl-pentapeptide in Bacillus megaterium by inhibiting active transport of amino acids incorporated into the pentapeptide. The ability of daptomycin to inhibit active transport and peptidoglycan formation may be due to its ability to disrupt the transmembrane electrochemical gradient.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.35.12.2639

Reference21 articles.

1. Alborn W. E. Jr. N. E. Allen J. E. Flokowitsch and D. A. Preston. 1990. Daptomycin has an effect upon the electrical potential of growing cells of Staphylococcus aureus. abstr. 839 p. 226. Program Abstr. 30th Intersci. Conf. Antimicrob. Agents Chemother.

2. Daptomycin disrupts membrane potential in growing Staphylococcus aureus;Alborn W. E.;Antimicrob. Agents Chemother.,1991

3. Inhibition of peptidoglycan biosynthesis in gram-positive bacteria by LY146032;Allen N. E.;Antimicrob. Agents Chemother.,1987

4. Lipoteichoic acid as a new target for activity of antibiotics: mode of action of daptomycin (LY146032);Canepari P.;Antimicrob. Agents Chemother.,1990

5. A21978C, a complex of new acidic peptide antibiotics: isolation, chemistry, and mass spectral structure elucidation;Debono M.;J. Antibiot.,1987

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