Author:
Bandeira Tereza de Jesus Pinheiro Gomes,Moreira Camila Alencar,Brilhante Raimunda Sâmia Nogueira,Castelo-Branco Débora de Souza Collares Maia,Neto Manoel Paiva de Araújo,Cordeiro Rossana de Aguiar,Rodrigues Terezinha de Jesus Santos,Rocha Marcos Fábio Gadelha,Sidrim José Júlio Costa
Abstract
ABSTRACTThis study aimed at investigating thein vitroactivities of amoxicillin-clavulanate, doxycycline, ceftazidime, imipenem, and trimethoprim-sulfamethoxazole againstBurkholderia pseudomalleiin planktonic and biofilm forms, through broth microdilution and resazurin-based viability staining, respectively. In planktonic growth, the strains were susceptible to the drugs, while in biofilm growth, significantly higher antimicrobial concentrations were required, especially for ceftazidime and imipenem, surpassing the resistance breakpoints. These results highlight the importance of the routine evaluation of biofilm antimicrobial susceptibility.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
12 articles.
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