Author:
Brilhante R. S. N.,Valente L. G. A.,Rocha M. F. G.,Bandeira T. J. P. G.,Cordeiro R. A.,Lima R. A. C.,Leite J. J. G.,Ribeiro J. F.,Pereira J. F.,Castelo-Branco D. S. C. M.,Monteiro A. J.,Sidrim J. J. C.
Abstract
ABSTRACTThis study aimed to evaluate thein vitrocombination of farnesol and β-lactams againstBurkholderia pseudomallei. A total of 12 β-lactamase-positive strains were tested according to CLSI standards. All strains were inhibited by farnesol, with MICs ranging from 75 to 150 μM. The combination of this compound with β-lactams resulted in statistically significant β-lactam MIC reduction (P≤ 0.05). This study provides new perspectives for the use of farnesol combined with β-lactam antibiotics against strains ofB. pseudomallei.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
26 articles.
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