LmrR Is a Transcriptional Repressor of Expression of the Multidrug ABC Transporter LmrCD in Lactococcus lactis-Reference-Cited by-同舟云学术

LmrR Is a Transcriptional Repressor of Expression of the Multidrug ABC Transporter LmrCD in Lactococcus lactis

Published:2008-01-15 Issue:2 Volume:190 Page:759-763
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Agustiandari Herfita¹,Lubelski Jacek²,van den Berg van Saparoea H. Bart¹,Kuipers Oscar P.²,Driessen Arnold J. M.¹

Affiliation:

1. Department of Molecular Microbiology

2. Department of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, NL-9751 NN Haren, The Netherlands

Abstract

ABSTRACT LmrCD is an ABC-type multidrug transporter in Lactococcus lactis . LmrR encodes a putative transcriptional regulator. In a Δ lmrR strain, lmrCD is up-regulated. LmrR binds the promoter region of lmrCD and interacts with drugs that cause lmrCD up-regulation. This suggests that LmrR is a drug-dependent transcriptional regulator of lmrCD expression.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.01151-07

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