Antibacterial effect of etoposide in vitro

Author:

Calame W1,van der Waals R1,Douwes-Idema N1,Mattie H1,van Furth R1

Affiliation:

1. Department of Infectious Diseases, University Hospital, Leiden, The Netherlands.

Abstract

Etoposide, an antitumor drug, had an effect in vitro against all strains of gram-positive bacteria studied but not against three gram-negative bacteria. The MICs ranged between 6.2 and 50 micrograms/ml. In short-term-growth experiments, etoposide had a bactericidal efficacy that was 10 to 50 times lower than that of cloxacillin.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference16 articles.

1. VP16-213 (etoposide). A critical review of its activity;Cavalli F.;Cancer Chemother. Pharmacol.,1982

2. Pharmacokinetics of VP16-213 in Lewis Iung carcinoma bearing mice;Colombo T.;Cancer Chemother. Pharmacol.,1982

3. Comparison of pharmacokinetics of VP16 in mice, rats and humans;Colombo T.;Proc. Am. Assoc. Cancer Res.,1983

4. Pharmacokinetics of VP16-213 given by different administration methods;D'Incalci M.;Cancer Chemother. Pharmacol.,1982

5. Pharmacokinetics of high-dose etoposide (VP-16-213) administered to cancer patients;Hande K. R.;Cancer Res.,1984

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