Genome Sequence of a Recently Emerged, Highly Transmissible, Multi-Antibiotic- and Antiseptic-Resistant Variant of Methicillin-Resistant Staphylococcus aureus , Sequence Type 239 (TW)-Reference-Cited by-同舟云学术

Genome Sequence of a Recently Emerged, Highly Transmissible, Multi-Antibiotic- and Antiseptic-Resistant Variant of Methicillin-Resistant Staphylococcus aureus , Sequence Type 239 (TW)

Published:2010-02 Issue:3 Volume:192 Page:888-892
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Holden Matthew T. G.¹,Lindsay Jodi A.²,Corton Craig¹,Quail Michael A.¹,Cockfield Joshua D.²,Pathak Smriti³,Batra Rahul⁴,Parkhill Julian¹,Bentley Stephen D.¹,Edgeworth Jonathan D.³⁴

Affiliation:

1. The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom

2. Centre for Infection, Department of Cellular & Molecular Medicine, St George's, University of London, Cranmer Terrace, London, United Kingdom

3. Department of Infectious Diseases, King's College London, Guy's, King's and St Thomas' Medical School, Guy's Hospital, London, United Kingdom

4. Directorate of Infection, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom

Abstract

ABSTRACT The 3.1-Mb genome of an outbreak methicillin-resistant Staphylococcus aureus (MRSA) strain (TW20) contains evidence of recently acquired DNA, including two large regions (635 kb and 127 kb). The strain is resistant to a wide range of antibiotics, antiseptics, and heavy metals due to resistance genes encoded on mobile genetic elements and also mutations in housekeeping genes.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.01255-09

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