Combinational Deletions of MGF110-9L and MGF505-7R Genes from the African Swine Fever Virus Inhibit TBK1 Degradation by an Autophagy Activator PIK3C2B To Promote Type I Interferon Production

Author:

Zhu Guoqiang12,Ren Jingjing1,Li Dan1ORCID,Ru Yi1,Qin Xiaodong1,Feng Tao1,Tian Hong1,Lu Bingzhou1,Shi Dongfang2,Shi Zhengwang1,Yang Wenping1,Zheng Haixue1ORCID

Affiliation:

1. State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

2. College of Veterinary Medicine, Northeast Agricultural University, Harbin, China

Abstract

African swine fever (ASF) is a contagious and lethal hemorrhagic disease of pigs caused by the African swine fever virus (ASFV), leading to significant economic consequences for the global pig industry. The development of an effective and safe ASF vaccine has been unsuccessful.

Funder

MOST | National Key Research and Development Program of China

The open competition program of top ten critical priorities of Agricultural Science and Technology innovation for the 14th-Five-Year Plan of Guangdong Province

Gansu major science and technology projects

Development of African swine fever subunit vaccine from Lanzhou Veterinary Research Institute

The technology Major Project of Gansu Province

The earmarked fund

The director's funding of Lanzhou Veterinary Research Institute

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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