Inhibition of Infectious HIV-1 Production by Rerouting the Cellular Furin Inhibitor Serpin B8-Reference-Cited by-同舟云学术

Inhibition of Infectious HIV-1 Production by Rerouting the Cellular Furin Inhibitor Serpin B8

Published:2023-06-29 Issue:6 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Petersen Moritz¹,Lotke Rishikesh¹,Hopfensperger Kristina¹,Victoria Sabina¹,Haußmann Isabell¹,Burster Timo²,Baldauf Hanna-Mari³,Sauter Daniel¹^ORCID

Affiliation:

1. Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany

2. School of Sciences and Humanities, Nazarbayev University, Astana, Kazakhstan

3. Max von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU Munich, Munich, Germany

Abstract

Many cellular proteases serve as dependency factors during viral infection and are hijacked by viruses for the maturation of their own (glyco)proteins. Consequently, inhibition of these cellular proteases may represent a means to inhibit the spread of viral infection.

Funder

Deutsches Zentrum für Infektionsforschung

Deutsche Forschungsgemeinschaft

Medical Faculty, Tuebingen University

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00294-23

Reference44 articles.

1. Furin‐mediated protein processing in infectious diseases and cancer

2. A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation

3. Alpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2–Priming Protease TMPRSS2

4. Serine Protease Inhibitors Restrict Host Susceptibility to SARS-CoV-2 Infections

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