Serine Protease Inhibitors Restrict Host Susceptibility to SARS-CoV-2 Infections-Reference-Cited by-同舟云学术

Serine Protease Inhibitors Restrict Host Susceptibility to SARS-CoV-2 Infections

Published:2022-06-28 Issue:3 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Rosendal Ebba¹²,Mihai Ionut Sebastian²³⁴⁵,Becker Miriam¹⁶⁷⁸,Das Debojyoti²³,Frängsmyr Lars¹,Persson B. David¹⁹,Rankin Gregory D.¹⁰¹¹,Gröning Remigius¹,Trygg Johan¹²¹³,Forsell Mattias¹^ORCID,Ankarklev Johan¹⁴¹⁵,Blomberg Anders¹⁰,Henriksson Johan²³,Överby Anna K.¹²^ORCID,Lenman Annasara¹^ORCID

Affiliation:

1. Department of Clinical Microbiology, Umeå University, Umeå, Sweden

2. Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå, Sweden

3. Department of Molecular Biology, Umeå University, Umeå, Sweden

4. Industrial Doctoral School, Umeå University, Umeå, Sweden

5. National Clinical Research School in Chronic Inflammatory Diseases (NCRSCID), Karolinska Institutet, Solna, Sweden

6. Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Medical School Hannover and the Helmholtz Centre for Infection Research, Hannover, Germany

7. Department of Biochemistry & Research Center for Emerging Infections and Zoonoses (RIZ), University of Veterinary Medicine Hannover, Hannover, Germany

8. Wallenberg Centre for Molecular Medicine (WCMM), Umeå University, Umeå, Sweden

9. Swedish National Veterinary Institute (SVA), Uppsala, Sweden

10. Department of Public Health and Clinical Medicine, Section of Medicine, Umeå University, Umeå, Sweden

11. Swedish Defence Research Agency, CBRN Defence and Security, Umeå, Sweden

12. Department of Chemistry, Umeå University, Umeå, Sweden

13. Sartorius Corporate Research, Umeå, Sweden

14. Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden

15. Microbial Single Cell Genomics Facility, SciLifeLab, Biomedical Center (BMC) Uppsala University, Uppsala, Sweden

Abstract

Identification of host factors affecting individual SARS-CoV-2 susceptibility will provide a better understanding of the large variations in disease severity and will identify potential factors that can be used, or targeted, in antiviral drug development. With the use of an advanced lung cell model established from several human donors, we identified cellular protease inhibitors, serpins, as host factors that restrict SARS-CoV-2 infection.

Funder

Hjärt-Lungfonden

Knut och Alice Wallenbergs Stiftelse

Svenska Sällskapet för Medicinsk Forskning

Kempestiftelserna

Vetenskapsrådet

Carl Bennet AB

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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