Papillomavirus E1 Protein Binds to and Stimulates Human Topoisomerase I-Reference-Cited by-同舟云学术

Papillomavirus E1 Protein Binds to and Stimulates Human Topoisomerase I

Published:2006-02 Issue:3 Volume:80 Page:1584-1587
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Clower Randolph V.¹,Fisk John C.¹,Melendy Thomas¹

Affiliation:

1. University at Buffalo, Department of Microbiology and Immunology and Witebsky Center for Microbial Pathogenesis, 210 Biomedical Research Building, School of Medicine and Biomedical Sciences, Buffalo, New York 14214

Abstract

ABSTRACT The papillomavirus (PV) E1 helicase plays a direct role in recruiting cellular DNA replication factors, such as replication protein A or polymerase α-primase, to replicate PV genomes. Here, E1 is shown to bind to human topoisomerase I and stimulate its relaxation activity up to sevenfold. The interaction between E1 and topoisomerase I was mapped to the E1 DNA binding domain and C terminus. These findings imply a mechanism for the recruitment of topoisomerase I to PV DNA replication forks and for stimulating topoisomerase I to allow for efficient relaxation of the torsional stress induced by replication fork progression.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.80.3.1584-1587.2006

Reference27 articles.

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