Coordination of the Cell Wall Integrity and High-Osmolarity Glycerol Pathways in Response to Ethanol Stress in Saccharomyces cerevisiae

Author:

Udom Nisarut12,Chansongkrow Pakkanan13,Charoensawan Varodom345,Auesukaree Choowong1267ORCID

Affiliation:

1. Department of Biology, Faculty of Science, Mahidol University, Bangkok, Thailand

2. Center of Excellence on Environmental Health and Toxicology, CHE, Ministry of Education, Bangkok, Thailand

3. Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand

4. Integrative Computational BioScience Center, Mahidol University, Nakhon Pathom, Thailand

5. Systems Biology of Diseases Research Unit, Faculty of Science, Mahidol University, Bangkok, Thailand

6. Department of Biotechnology, Faculty of Science, Mahidol University, Bangkok, Thailand

7. Mahidol University-Osaka University Collaborative Research Center for Bioscience and Biotechnology, Faculty of Science, Mahidol University, Bangkok, Thailand

Abstract

The budding yeast Saccharomyces cerevisiae has been widely used in industrial fermentations, including the production of alcoholic beverages and bioethanol. During fermentation, an increased ethanol concentration is the main stress that affects yeast metabolism and inhibits ethanol production. This work presents evidence that in response to ethanol stress, both CWI and HOG pathways cooperate to control the expression of cell wall-remodeling genes in order to build the adaptive strength of the cell wall. These findings will contribute to a better understanding of the molecular mechanisms underlying adaptive responses and tolerance of yeast to ethanol stress, which is essential for successful engineering of yeast strains for improved ethanol tolerance.

Funder

Center of Excellence on Environmental Health and Toxicology

Science Achievement Scholarship of Thailand

Royal Society-OHEC Newton Mobility Grant

Thailand Research Fund

Mahidol University | Faculty of Science, Mahidol University

Crown Property Bureau

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

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