Antifungal Susceptibility Profiles and Drug Resistance Mechanisms of Clinical Lomentospora prolificans Isolates

Abstract

Lomentospora prolificans is an opportunistic fungal pathogen with low susceptibility to current antifungal drugs. Here, we tested the in vitro susceptibility of 8 drugs against 42 clinical L. prolificans isolates. All isolates showed high MICs to voriconazole (MIC 90 >16 μg/ml), itraconazole (MIC 90 >16 μg/ml), posaconazole (MIC 90 >16 μg/ml), isavuconazole (MIC 90 >16 μg/ml), amphotericin B (MIC 90 >16 μg/ml), and terbinafine (MIC 90 >64 μg/ml) and high minimum effective concentrations (MECs) to micafungin (MEC 90 >8 μg/ml), with the exception of miltefosine showing an MIC 90 value of 4 μg/ml.