Affiliation:
1. Department of Developmental Therapeutics, The University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Houston, Texas 77025
Abstract
Pirbenicillin is a new semisynthetic penicillin which inhibited 67% of isolates of
Proteus aeruginosa
tested in our laboratory, 93% of
P. mirabilis
, 31% of
Enterobacter
spp., 41% of
Serratia
spp., and 58% of
Escherichia coli
at a concentration of 6.25 μg/ml. Its activity appeared to be inoculum dependent and it was virtually inactive against 10
7
inocula of
P. aeruginosa
. It was more active than carbenicillin or ticarcillin, but less active than BL-P1654 against
P. aeruginosa
. Carbenicillin and ticarcillin appeared to be more active than pirbenicillin against
Proteus
spp., but pirbenicillin was active against some isolates of
Klebsiella
spp.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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