Affiliation:
1. Department of Developmental Therapeutics, The University of Texas M. D. Anderson Hospital and Tumor Institute, Houston, Texas 77025
Abstract
The activity of three α-(substituted-ureido) penicillins was evaluated in vitro against 599 clinical isolates of gram-negative bacilli, by use of the broth-dilution technique. At a concentration of 12.5 μg or less/ml, BL-P1597 inhibited 90% of isolates of
Pseudomonas
sp., 56% of
Enterobacter
sp., 67% of indole-positive
Proteus
spp., 72% of
Escherichia coli
, and 85% of
Proteus mirabilis.
BL-P1654 had similar activity, whereas BL-P1532 was much less active. At a concentration of 25 μg or less/ml, BL-P1597 also inhibited nearly 60% of isolates of
Klebsiella
sp. and nearly 40% of
Serratia
sp. BL-P1597 and BL-P1654 were as active as ampicillin and carbenicillin against
E. coli
and
P. mirabilis.
They were less active than carbenicillin against indole-positive
Proteus
spp. Both drugs were substantially more active than carbenicillin against
Pseudomonas
sp. A strain of
Pseudomonas
sp. which developed resistance to carbenicillin also developed resistance to the α-(substituted-ureido) penicillins simultaneously.
Publisher
American Society for Microbiology
Subject
General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine
Cited by
12 articles.
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