Affiliation:
1. The University of Texas M. D. Anderson Hospital and Tumor Institute, Houston, Texas 77025
Abstract
The activity of 6-(D-α-sulfoaminophenylacetamido)-penicillanic acid was determined against 357 clinical isolates of gram-negative bacilli by use of the tube-dilution technique. The majority of the isolates of
Pseudomonas
species were inhibited by 200 μg/ml or less of this antibiotic. Most of the isolates of
Escherichia coli
had a minimal inhibitory concentration of 50 μg/ml or less. Seventy-three per cent of the isolates of
P. mirabilis
, 40% of the isolates of
P. morganii
, and 45% of the isolates of
Enterobacter
species were inhibited by 12.5 μg/ml or less, whereas most of the isolates of
Klebsiella
species and
Serratia
species were resistant. The activity of this semisynthetic penicillin was affected by the size of the inoculum. The drug was bactericidal against all isolates of
E. coli
and
Proteus
species that were sensitive to it, but it was bactericidal against only 32% of the sensitive isolates of
Pseudomonas
species.
Publisher
American Society for Microbiology
Subject
General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine
Cited by
4 articles.
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