A Cell Culture Model of BK Polyomavirus Persistence, Genome Recombination, and Reactivation

Author:

Zhao Linbo1ORCID,Imperiale Michael J.12

Affiliation:

1. Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA

2. Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, USA

Abstract

BK polyomavirus (BKPyV) generally establishes a persistent subclinical infection in healthy individuals but can cause severe disease in transplant recipients. While an in vitro model to study acute replication exists, no practical model with which to study BKPyV persistence is currently available.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Reference43 articles.

1. DeCaprio JA, Imperiale MJ, Major EO. 2013. Polyomaviruses. In Knipe DM, Howley PM, Cohen JI, Griffin DE, Lamb RA, Martin MA, Racaniello VR, Roizman B (ed), Fields virology, 6th ed. Lippincott Williams & Wilkins, Philadelphia, PA.

2. NEW HUMAN PAPOVAVIRUS (B.K.) ISOLATED FROM URINE AFTER RENAL TRANSPLANTATION

3. CULTIVATION OF PAPOVA-LIKE VIRUS FROM HUMAN BRAIN WITH PROGRESSIVE MULTIFOCAL LEUCOENCEPHALOPATHY

4. Seroepidemiology of Human Polyomaviruses

5. Optimizing JC and BK polyomavirus IgG testing for seroepidemiology and patient counseling

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