Efficacy of APX2039 in a Rabbit Model of Cryptococcal Meningitis-Reference-Cited by-同舟云学术

Efficacy of APX2039 in a Rabbit Model of Cryptococcal Meningitis

Published:2022-12-20 Issue:6 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Giamberardino Charles D.¹^ORCID,Schell Wiley A.¹,Tenor Jennifer L.¹,Toffaletti Dena L.¹,Palmucci Julia R.¹,Marius Choiselle²,Boua Jane-Valeriane K.³,Soltow Quinlyn⁴,Mansbach Robert⁵,Moseley M. Arthur⁶,Thompson J. Will⁶,Dubois Laura G.⁶,Hope William⁷^ORCID,Perfect John R.¹^ORCID,Shaw Karen Joy⁸

Affiliation:

1. Duke University School of Medicine, Department of Medicine, Division of Infectious Diseases, Durham, North Carolina, USA

2. Duke University School of Medicine, Department of Surgery, Durham, North Carolina, USA

3. Duke University School of Medicine, Department of Neurosurgery, Durham, North Carolina, USA

4. Pfizer, Inc., La Jolla, California, USA

5. Mansbach Consulting, LLC, San Diego, California, USA

6. Duke University School of Medicine, Duke Proteomics and Metabolomics Core Facility, Center for Genomic and Computational Biology, Durham, North Carolina, USA

7. Antimicrobial Pharmacodynamics and Therapeutics, University of Liverpool, Liverpool Health Partners, Liverpool, United Kingdom

8. Hearts Consulting Group, LLC, Poway, California, USA

Abstract

Cryptococcal meningitis (CM) is a fungal disease with significant global morbidity and mortality. The gepix Gwt1 inhibitors are a new class of antifungal drugs.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

NIH Therapeutics for Rare and Neglected Diseases (TRND) Program

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.02347-22

Reference40 articles.

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2. Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS

3. Anonymous. 2018. WHO guidelines approved by the Guidelines Review Committee, guidelines for the diagnosis, prevention and management of cryptococcal disease in HIV-infected adults, adolescents and children: supplement to the 2016 consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection. World Health Organization, Geneva, Switzerland.

4. Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis

5. Clinical Practice Guidelines for the Management of Cryptococcal Disease: 2010 Update by the Infectious Diseases Society of America

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