Oxidative Phosphorylation Is Required for Powering Motility and Development of the Sleeping Sickness Parasite Trypanosoma brucei in the Tsetse Fly Vector-Reference-Cited by-同舟云学术

Oxidative Phosphorylation Is Required for Powering Motility and Development of the Sleeping Sickness Parasite Trypanosoma brucei in the Tsetse Fly Vector

Published:2022-02-22 Issue:1 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Dewar Caroline E.¹^ORCID,Casas-Sanchez Aitor²³^ORCID,Dieme Constentin⁴^ORCID,Crouzols Aline⁴,Haines Lee R.²^ORCID,Acosta-Serrano Álvaro²³^ORCID,Rotureau Brice⁴^ORCID,Schnaufer Achim¹^ORCID

Affiliation:

1. Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom

2. Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

3. Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

4. Trypanosome Transmission Group, Trypanosome Cell Biology Unit, Institut Pasteur and INSERM U1201, Paris, France

Abstract

African trypanosomes cause disease in humans and their livestock and are transmitted by tsetse flies. The insect ingests these parasites with its blood meal, but to be transmitted to another mammal, the trypanosome must undergo complex development within the tsetse fly and migrate from the insect's gut to its salivary glands.

Funder

UKRI | Biotechnology and Biological Sciences Research Council

Institut Pasteur

Agence Nationale de la Recherche

GlycoPar-EU FP7 Marie Curie Initial Training Network

UKRI | Medical Research Council

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.02357-21