Metabolic reprogramming during the Trypanosoma brucei life cycle

Author:

Smith Terry K.,Bringaud FrédéricORCID,Nolan Derek P.ORCID,Figueiredo Luisa M.ORCID

Abstract

Cellular metabolic activity is a highly complex, dynamic, regulated process that is influenced by numerous factors, including extracellular environmental signals, nutrient availability and the physiological and developmental status of the cell. The causative agent of sleeping sickness, Trypanosoma brucei, is an exclusively extracellular protozoan parasite that encounters very different extracellular environments during its life cycle within the mammalian host and tsetse fly insect vector. In order to meet these challenges, there are significant alterations in the major energetic and metabolic pathways of these highly adaptable parasites. This review highlights some of these metabolic changes in this early divergent eukaryotic model organism.

Funder

Agence Nationale de la Recherche

Centre National de la Recherche Scientifique

Science Foundation Ireland

Engineering and Physical Sciences Research Council

Howard Hughes Medical Institute

Fundação para a Ciencia e Tecnologia

Biotechnology and Biological Sciences Research Council

European Community Seventh Framework Programme

Wellcome Trust

Medical Research Council

Publisher

F1000 Research Ltd

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

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