Quinolone resistance in clinical isolates of Serratia marcescens

Author:

Fujimaki K1,Fujii T1,Aoyama H1,Sato K1,Inoue Y1,Inoue M1,Mitsuhashi S1

Affiliation:

1. Episome Institute, Fujimi-mura, Seta-gun, Japan.

Abstract

The uptakes of norfloxacin by quinolone-resistant and -susceptible strains of Serratia marcescens were almost the same and 50% inhibitory concentrations for DNA gyrase and the MICs of quinolones were correlated, suggesting that DNA gyrase alterations are the basis of quinolone resistance.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference21 articles.

1. Purification of Citrobacter freundii DNA gyrase and inhibition by quinolones;Aoyama H.;Antimicrob. Agents Chemother.,1988

2. Norfloxacin resistance in a clinical isolate of Escherichia coli;Aoyama H.;Antimicrob. Agents Chemother.,1987

3. Studies on the mechanism of action of nalidixic acid;Bourguignon G. J.;Antimicrob. Agents Chemother.,1973

4. Crook S. M. J. B. Selken and P. D. McLardy-Smith. 1985. Clinical resistance to long-term oral ciprofloxacin. Lancet i: 1275.

5. Resistance mechanisms of Serratia marcescens against quinolones;Fujii T.;Rev. Infect. Dis.,1988

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