Norfloxacin resistance in a clinical isolate of Escherichia coli

Author:

Aoyama H1,Sato K1,Kato T1,Hirai K1,Mitsuhashi S1

Affiliation:

1. Episome Institute, Gunma, Japan.

Abstract

Analysis of DNA gyrase supercoiling and of norfloxacin uptake in Escherichia coli GN14176, a moderately norfloxacin-resistant clinical isolate, indicated that resistance was associated with both an altered drug target and a reduction in drug uptake.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference14 articles.

1. Studies on the mechanism of action of nalidixic acid;Bourguignon G. L.;Antimicrob. Agents Chemother.,1973

2. Brenner D. J. 1984. Facultatively anaerobic gram-negative rods p. 408-420. In N. R. Krieg and J. G. Holt (ed.) Bergey's manual of systematic bacteriology vol. 1. The Williams & Wilkins Co. Baltimore.

3. DNA gyrase: purification and catalytic properties of a fragment of gyrase B protein;Gellert M.;Proc. Natl. Acad. Sci. USA,1979

4. Nalidixic acid resistance: a second genetic character involved in DNA gyrase activity;Gellert M.;Proc. Natl. Acad. Sci. USA,1977

5. Escherichia coli K-12 mutants resistant to nalidixic acid: genetic mapping and dominance studies;Hane M. W.;J. Bacteriol.,1969

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3