Affiliation:
1. Episome Institute, Gunma, Japan.
Abstract
Analysis of DNA gyrase supercoiling and of norfloxacin uptake in Escherichia coli GN14176, a moderately norfloxacin-resistant clinical isolate, indicated that resistance was associated with both an altered drug target and a reduction in drug uptake.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference14 articles.
1. Studies on the mechanism of action of nalidixic acid;Bourguignon G. L.;Antimicrob. Agents Chemother.,1973
2. Brenner D. J. 1984. Facultatively anaerobic gram-negative rods p. 408-420. In N. R. Krieg and J. G. Holt (ed.) Bergey's manual of systematic bacteriology vol. 1. The Williams & Wilkins Co. Baltimore.
3. DNA gyrase: purification and catalytic properties of a fragment of gyrase B protein;Gellert M.;Proc. Natl. Acad. Sci. USA,1979
4. Nalidixic acid resistance: a second genetic character involved in DNA gyrase activity;Gellert M.;Proc. Natl. Acad. Sci. USA,1977
5. Escherichia coli K-12 mutants resistant to nalidixic acid: genetic mapping and dominance studies;Hane M. W.;J. Bacteriol.,1969
Cited by
72 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献