Antibacterial Properties of Gemifloxacin and Trovafloxacin in Urine Ex Vivo: Phase I Study-Reference-Cited by-同舟云学术

Antibacterial Properties of Gemifloxacin and Trovafloxacin in Urine Ex Vivo: Phase I Study

Published:2001-06 Issue:6 Volume:45 Page:1876-1878
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Garcı́a-Calvo Gloria¹,Parra Araceli¹,Aguilar Lorenzo²,Ponte Carmen¹,Giménez Marı́a J.²,Carcas Antonio³,Kinzig-Schippers Martina⁴,Soriano Francisco¹

Affiliation:

1. Medical Microbiology Department, Fundación Jiménez Dı́az,1

2. Medical Department, GlaxoSmithKline, Tres Cantos,2 and

3. Clinical Pharmacology Unit, Universidad Autónoma,3 Madrid, Spain, and

4. IBMP—Institute of Pharmaceutical Research, Nürnberg-Heroldsberg, Germany4

Abstract

ABSTRACT Urine bactericidal titers (UBTs) against Escherichia coli ATCC 25922 and Staphylococcus saprophyticus ATCC 1970 were determined after the administration of single oral doses of gemifloxacin at 320 mg and trovafloxacin at 200 mg to healthy volunteers. Gemifloxacin presented significantly lower experimental versus mathematically predicted UBTs over 72 h, due to the effect of urine on the susceptibility of the E. coli strain. Experimental UBTs were significantly higher for gemifloxacin than trovafloxacin against both strains over 72 h.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.45.6.1876-1878.2001

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