Design and virtual screening of novel fluoroquinolone analogs as effective mutant DNA GyrA inhibitors against urinary tract infection-causing fluoroquinolone resistant Escherichia coli-Reference-Cited by-同舟云学术

Design and virtual screening of novel fluoroquinolone analogs as effective mutant DNA GyrA inhibitors against urinary tract infection-causing fluoroquinolone resistant Escherichia coli

Published:2018 Issue:42 Volume:8 Page:23629-23647
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Balasubramaniyan Sakthivel¹²³⁴⁵^ORCID,Irfan Navabshan¹²³⁴⁵^ORCID,Umamaheswari Appavoo¹²³⁴⁵^ORCID,Puratchikody Ayarivan¹²³⁴⁵^ORCID

Affiliation:

1. Drug Discovery and Development Research Group

2. Department of Pharmaceutical Technology

3. University College of Engineering

4. Anna University

5. Tiruchirapalli-62024

Abstract

Design and development of novel fluoroquinolones analogs using target (mutant DNA GyrA), ligand-based SAR and virtual screening techniques.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/RA/C8RA01854E

Reference40 articles.

1. Immunity to uropathogens: the emerging roles of inflammasomes

2. Determinants of quinolone resistance in Escherichia coli causing community-acquired urinary tract infection in Bejaia, Algeria

3. Suppression of gyrase-mediated resistance by C7 aryl fluoroquinolones

4. gyrA Mutations in high-level fluoroquinolone-resistant clinical isolates of Escherichia coli

5. Fluoroquinolone Resistance Among Gram-Negative Urinary Tract Patho-gens: Global Smart Program Results, 2009-2010

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