A Leucyl-tRNA Synthetase Inhibitor with Broad-Spectrum Antimycobacterial Activity-Reference-Cited by-同舟云学术

A Leucyl-tRNA Synthetase Inhibitor with Broad-Spectrum Antimycobacterial Activity

Published:2021-04-19 Issue:5 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ganapathy Uday S.¹,González del Rio Rubén²,Cacho-Izquierdo Mónica²,Ortega Fátima²,Lelièvre Joël²,Barros-Aguirre David²^ORCID,Lindman Marissa¹,Dartois Véronique¹³^ORCID,Gengenbacher Martin¹³^ORCID,Dick Thomas¹³⁴^ORCID

Affiliation:

1. Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA

2. Global Health R&D, GlaxoSmithKline, Tres Cantos, Spain

3. Department of Medical Sciences, Hackensack Meridian School of Medicine, Nutley, New Jersey, USA

4. Department of Microbiology and Immunology, Georgetown University, Washington, DC, USA

Abstract

Global infections by nontuberculous mycobacteria (NTM) are steadily rising. New drugs are needed to treat NTM infections, but the NTM drug pipeline remains poorly populated and focused on repurposing or reformulating approved antibiotics.

Funder

Cystic Fibrosis Foundation

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02420-20

Reference54 articles.

1. The Taxonomy of the Genus Mycobacterium

3. Non-tuberculous mycobacteria and the rise of Mycobacterium abscessus