Engineering the Modular Receptor-Binding Proteins of Klebsiella Phages Switches Their Capsule Serotype Specificity-Reference-Cited by-同舟云学术

Engineering the Modular Receptor-Binding Proteins of Klebsiella Phages Switches Their Capsule Serotype Specificity

Published:2021-06-29 Issue:3 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Latka Agnieszka¹²^ORCID,Lemire Sebastien³,Grimon Dennis¹,Dams Dorien¹,Maciejewska Barbara²,Lu Timothy³⁴⁵⁶⁷,Drulis-Kawa Zuzanna²^ORCID,Briers Yves¹^ORCID

Affiliation:

1. Department of Biotechnology, Ghent University, Ghent, Belgium

2. Department of Pathogen Biology and Immunology, University of Wroclaw, Wroclaw, Poland

3. Synthetic Biology Group, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

4. Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

5. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

6. Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

7. Broad Institute, Cambridge, Massachusetts, USA

Abstract

The antimicrobial resistance crisis has rekindled interest in bacteriophage therapy. Phages have been studied over a century as therapeutics to treat bacterial infections, but one of the biggest challenges for the use of phages in therapeutic interventions remains their high specificity.

Funder

National Science Centre

UGent | Bijzonder Onderzoeksfonds UGent

Fonds voor Wetenschapelijk Onderzoek

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00455-21

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1. Retargeting R-Type Pyocins To Generate Novel Bactericidal Protein Complexes