Characterization of the Mode of Action of Aurodox, a Type III Secretion System Inhibitor from Streptomyces goldiniensis-Reference-Cited by-同舟云学术

Characterization of the Mode of Action of Aurodox, a Type III Secretion System Inhibitor from Streptomyces goldiniensis

Published:2019-02 Issue:2 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

McHugh Rebecca E.¹²,O’Boyle Nicky¹,Connolly James P. R.¹,Hoskisson Paul A.²^ORCID,Roe Andrew J.¹^ORCID

Affiliation:

1. Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom

2. Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom

Abstract

Recent work has demonstrated that the polyketide natural product Aurodox from Streptomyces goldiniensis is able to block the pathogenesis of the murine pathogen Citrobacter rodentium . In this work, we aimed to gain a better understanding of the mechanism of action of the compound.

Funder

RCUK | Biotechnology and Biological Sciences Research Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00595-18

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