blaNDM-5Carried by an IncX3 Plasmid in Escherichia coli Sequence Type 167

Abstract

ABSTRACTblaNDM-5was found inEscherichia colistrain 0215 from a Chinese patient without travel history. Genomic sequencing and conjugation experiments were performed. Strain 0215 belonged to sequence type 167 (ST167) and had other resistance determinants, includingblaTEM-135,blaCTX-M-14, andaac(6′)-Ib. blaNDM-5was carried by a 47-kb self-transmissible IncX3 plasmid and was in a complex genetic context similar to that ofblaNDM-1on IncX3 plasmids. IncX3 plasmids might have emerged as a common vehicle mediating the spread ofblaNDM.