False-Positive Carbapenem-Hydrolyzing Confirmatory Tests Due to ACT-28, a Chromosomally Encoded AmpC with Weak Carbapenemase Activity from Enterobacter kobei-Reference-Cited by-同舟云学术

False-Positive Carbapenem-Hydrolyzing Confirmatory Tests Due to ACT-28, a Chromosomally Encoded AmpC with Weak Carbapenemase Activity from Enterobacter kobei

Published:2019-05 Issue:5 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Jousset Agnès B.¹²³⁴,Oueslati Saoussen²⁴,Bernabeu Sandrine¹²³⁴,Takissian Julie²,Creton Elodie³,Vogel Anaïs³,Sauvadet Aimie³,Cotellon Garance³,Gauthier Lauraine¹²³⁴,Bonnin Rémy A.²³⁴,Dortet Laurent¹²³⁴,Naas Thierry¹²³⁴^ORCID

Affiliation:

1. Bacteriology-Hygiene Unit, Assistance Publique/Hôpitaux de Paris, Bicêtre Hospital, Le Kremlin-Bicêtre, France

2. EA 7361 (Structure, dynamic, function and expression of broad spectrum β-lactamases), Faculty of Medicine University Paris-Sud, University Paris-Saclay, Le Kremlin-Bicêtre, France

3. French National Reference Center for Antibiotic Resistance: Carbapenemase Producing Enterobacteriaceae, Le Kremlin-Bicêtre, France

4. Joint Research Unit EERA (Evolution and Ecology of Resistance to Antibiotics), Institut Pasteur-APHP-University Paris Sud, Paris, France

Abstract

In Enterobacter cloacae complex (ECC), the overproduction of the chromosome-encoded cephalosporinase (cAmpC) associated with decreased outer membrane permeability may result in carbapenem resistance. In this study, we have characterized ACT-28, a cAmpC with weak carbapenemase activity, from a single Enterobacter kobei lineage.

Funder

Université Paris Sud

Agence Nationale de la Recherche

Assistance Publique - Hôpitaux de Paris

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02388-18

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1. Enterobacter spp.: pathogens poised to flourish at the turn of the century