Optimizing Strategies for Bio-Based Ethanol Production Using Genome-Scale Metabolic Modeling of the Hyperthermophilic Archaeon, Pyrococcus furiosus-Reference-Cited by-同舟云学术

Optimizing Strategies for Bio-Based Ethanol Production Using Genome-Scale Metabolic Modeling of the Hyperthermophilic Archaeon, Pyrococcus furiosus

Published:2023-06-28 Issue:6 Volume:89 Page:
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Vailionis Jason L.¹,Zhao Weishu¹,Zhang Ke¹,Rodionov Dmitry A.²,Lipscomb Gina L.³,Tanwee Tania N. N.³,O'Quinn Hailey C.³,Bing Ryan G.⁴,Kelly Robert M.⁴^ORCID,Adams Michael W. W.³^ORCID,Zhang Ying¹^ORCID

Affiliation:

1. Department of Cell and Molecular Biology, College of the Environment and Life Sciences, University of Rhode Island, Kingston, Rhode Island, USA

2. Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, California, USA

3. Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA

4. Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, USA

Abstract

The bio-based production of organic chemicals provides a sustainable alternative to fossil-based production in the face of today’s climate challenges. In this work, we present a genome-scale metabolic reconstruction of Pyrococcus furiosus , a well-established platform organism that has been engineered to produce a variety of chemicals and fuels.

Funder

U.S. Department of Energy

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/aem.00563-23

Reference62 articles.

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1. Manipulating Fermentation Pathways in the Hyperthermophilic Archaeon Pyrococcus furiosus for Ethanol Production up to 95°C Driven by Carbon Monoxide Oxidation;Applied and Environmental Microbiology;2023-06-28