Function of the Respiratory Syncytial Virus Small Hydrophobic Protein-Reference-Cited by-同舟云学术

Function of the Respiratory Syncytial Virus Small Hydrophobic Protein

Published:2007-08 Issue:15 Volume:81 Page:8361-8366
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Fuentes Sandra¹²,Tran Kim C.³,Luthra Priya⁴,Teng Michael N.²³⁵,He Biao¹²⁴⁵

Affiliation:

1. Department of Veterinary and Biomedical Sciences

2. Graduate Program in Pathobiology

3. Department of Biochemistry and Molecular Biology

4. Cell and Developmental Biology Option, The Huck Institutes of Life Sciences

5. Center of Molecular Immunology and Infectious Disease, Pennsylvania State University, University Park, Pennsylvania 16802

Abstract

ABSTRACT Respiratory syncytial virus (RSV), a member of the Paramyxoviridae family, encodes a small hydrophobic (SH) protein of unknown function. Parainfluenza virus 5 (PIV5), a prototypical paramyxovirus, also encodes an SH protein, which inhibits tumor necrosis factor alpha (TNF-α) signaling. In this study, recombinant PIV5 viruses without their own SH but containing RSV SH (from RSV strain A2 or B1) in its place (PIV5ΔSH-RSV SH) and RSV lacking its own SH (RSVΔSH) were generated and analyzed. The results indicate that the SH protein of RSV has a function similar to that of PIV5 SH and that it can inhibit TNF-α signaling.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02717-06

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