Assessing the Genetic Diversity of the Aldolase Genes of Plasmodium falciparum and Plasmodium vivax and Its Potential Effect on Performance of Aldolase-Detecting Rapid Diagnostic Tests-Reference-Cited by-同舟云学术

Assessing the Genetic Diversity of the Aldolase Genes of Plasmodium falciparum and Plasmodium vivax and Its Potential Effect on Performance of Aldolase-Detecting Rapid Diagnostic Tests

Published:2006-12 Issue:12 Volume:44 Page:4547-4549
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Lee Nelson¹²,Baker Joanne²,Bell David³,McCarthy James¹,Cheng Qin²

Affiliation:

1. The Australian Centre for International and Tropical Health, a Joint Program of the Queensland Institute of Medical Research and the School of Population Health, University of Queensland, Brisbane, Australia

2. Department of Drug Resistance and Diagnostics, Australian Army Malaria Institute, Brisbane, Australia

3. World Health Organization—Regional Office for the Western Pacific, Manila, Philippines

Abstract

ABSTRACT Malaria-specific rapid diagnostic tests (RDTs) targeting aldolase show highly variable sensitivities. We assessed diversity in Plasmodium falciparum and P. vivax aldolases by sequencing the coding genes from parasites of various origins. The results show that aldolases are highly conserved, indicating that antigenic diversity is not a cause of variable RDT sensitivity.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.01611-06

Reference15 articles.

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