Synthesis of Cephalosporin C from Sulfate by Mutants of Cephalosporium acremonium-Reference-Cited by-同舟云学术

Synthesis of Cephalosporin C from Sulfate by Mutants of Cephalosporium acremonium

Published:1973-10 Issue:4 Volume:4 Page:474-478
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Niss H. F.¹,Nash C. H.¹

Affiliation:

1. Antibiotic Manufacturing and Development Division, Eli Lilly and Company, Indianapolis, Indiana 46206

Abstract

The innate ability of Cephalosporium acremonium to use methionine preferentially over sulfate for synthesis of cephalosporin C can be influenced through mutation. Mutants of C. acremonium with altered capacity to utilize sulfate for synthesis of antibiotic were isolated and partially characterized with respect to the uptake of sulfate and the regulation of arylsulfatase.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.4.4.474

Reference23 articles.

1. Specificity and regulation of methionine transport in filamentous fungi;Benko P. V.;Arch. Biochem. Biophys.,1967

2. Colorimetric determination of benzyl penicillin;Boxer G. E.;Anal. Chem.,1949

3. Role of methionine in cephalosporin synthesis;Caltrider P. G.;Appl. Microbiol.,1966

4. Enzymatic synthesis and cleavage of cystathionine in fungi and bacteria;Delavier-Klutchko C.;J. Biol. Chem.,1965

5. Biosynthesis of cephalosporin C;Demain A. L.;Appl. Microbiol.,1962

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